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P-glycoprotein is well known for decreasing the efficacy of various drug administrations due to its ability to export intracellular levels of absorbed drug to the cell exterior

The International Federation of Gynecology and Obstetrics (FIGO) staging remains the single most important prognostic factor: five-year relative survival approaches 92% when disease is confined to the ovaries (stage I) but falls to 32% with distant metastasis (stage IV) [46, 47]

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Possible side effects include abdominal pain and bloating, diarrhea, and gout

These processes not only sustain oncogenic signaling and protect critical cellular components but also reshape the TME to counteract various therapeutic strategies, ultimately promoting treatment resistance

However, this would probably only happen with a very high intake of aspartame